Top Best Nightclubs in Tenderloin, San Francisco, CA [2020 GUIDE]

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With over 43 venues in San Francisco, there are many places to choose from whether you're looking for a crazy night out or a lounge atmosphere. Don't worry! We're going to list out the best clubs in Tenderloin, San Francisco that you should definitely check out.

Infusion Lounge

Best nightclub in Tenderloin, San Francisco!
Infusion Lounge

Infusion Lounge creates a sensory experience of taste, touch, sight and sound. Alluring, sophisticated, provocative and contemporary, Infusion SF offers an unparalleled experience. Located in the heart of San Francisco’s Union Square, Infusion Lounge has transformed Bay Area nightlife and private events since its inception in 2009. One of the most successful clubs in the city, it continues to showcase some of the world’s biggest DJs and hottest performing acts. Notable performers have included LMFAO, Lil Jon, and Chromeo. From the minute guests walk into the exotic lounge, they are instantly transported to another world. A sleek-entertainment venue which combines classic and modern Hong Kong luxury design, Infusion Lounge features richly textured surfaces, undulating mosaic walls, intriguing Asian statues, gender-bending provocative uni-sex bathrooms and plush furnishings. The sultry design compliments the state-of-the-art sound systems and lighting to give even the most polished music venues a run for their money. The 6500 sq. ft of entertainment space features private rooms, state-of-the-art sound and lighting systems, hypnotic LED-illuminated glass columns, and an exotic Asian-inspired interior with giant lacquer dragons, laughing Buddhas, and glowing lattice walls.

  • 124 Ellis Street San Francisco, CA 94102 United States
  • Tenderloin
  • 10 PM - 2 AM Wed - Sat
  • Dress Code: Strict
  • $$$

Great American Music Hall

Great American Music Hall

Voted #6 in the Best Clubs in America list by Rolling Stone magazine in 2013, San Francisco’s oldest and grandest nightclub, the Great American Music Hall carries guests back to an earlier, more elegant era, with its ornate balconies, soaring marble columns and elaborate ceiling frescoes. Long-time customers and newcomers alike feel at home in the 5,000-square-foot concert hall that symbolized renewal and optimism when it opened in 1907. Today, a professional sound and lighting system, two full bars, a modern kitchen and a spacious oak dance floor help to blend contemporary quality with turn-of-the-century graciousness.

  • 859 O'Farrell St San Francisco, CA 94109 United States
  • Tenderloin
  • Varies depending on events
  • Dress Code: Casual
  • $$

Check out the venues section for the full list of nightclubs.

San Francisco Nightclubs FAQ

What time does the headlining DJ usually start performing in San Francisco clubs?

The headlining DJ will usually start performing around 12:00 AM.

How long do DJs play in San Francisco?

The headlining DJ or artist usually plays a 1 to 2 hour set.

What is the dress code like at San Francisco nightclubs?

Guys can wear nice jeans and a form fitting plain t-shirt or a nice button down shirt. Girls can wear jeans or a comfortable but stylish dress if they prefer. Of course guys and girls can never go wrong with dressing up even more – there is no such thing as overdressing when it comes to clubs.

How can I get into San Francisco nightclubs for free?

Some San Francisco nightclubs have a free ladies guest list, and have a free even ratio guest list – free if you have the same number of girls (or more) in your party.

Keep in mind that many San Francisco nightclubs are more exclusive and require bottle service to get in. You can sign up for the guest list on our events page.

How can I book bottle service for San Francisco nightclubs?

You can book bottle service directly on Discotech by visiting the San Francisco page.

How much is bottle service at San Francisco clubs?

Bottle service and table minimums at nightclubs can get pretty expensive in San Francisco, but every nightclub is different.

The best way to find out is to visit the events page and choose the event you're thinking of going.

Should I buy tickets to get into San Francisco nightclubs?

If the nightclub has tickets, we recommend buying tickets during holiday weekends and for big name artists. The ticket line is generally faster and shorter than the guest list.

Many nightclubs in San Francisco are bottle service only – meaning you must book a table reservation in order to get inside.

Which San Francisco nightclubs play EDM and electronic music?

Check out the full list on our guide to the best EDM nightclubs in San Francisco.

Which San Francisco nightclubs play hip-hop?

Check out the full list on our guide to the best hip hop nightclubs in San Francisco.